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1.What is the Ethyl isocyanoacetate ?
Ethyl isocyanoacetate is a versatile cyclization synthon that is characterized by its light yellow to brown liquid appearance. It is slightly soluble in water and lye, but miscible in ethanol and ether. The material may darken upon storage, which is an important consideration for its handling and use.
Usage:
Ethyl isocyanoacetate is used as a cyclization synthon for the preparation of various heterocyclic compounds, including pyrroles, oxazolines, benzodiazepines, oxazoles, and imidazoles. Its ability to participate in the synthesis of these compounds makes it a valuable reagent in the field of organic chemistry.
Used in Pharmaceutical Industry:
Ethyl isocyanoacetate is used as a key intermediate in the synthesis of various pharmaceutical compounds. For example, it is involved in the synthesis of 1H-indole-2-carboxylate by condensing with 2-bromo benzenealdehyde using CuI as a catalyst. This application is crucial for the development of new drugs and therapeutic agents.
Used in Chemical Synthesis:
Ethyl isocyanoacetate is used as a precursor in the preparation of ethyl thiazole-4-carboxylate upon reaction with O-ethyl thioformate. This application highlights its utility in the synthesis of complex organic molecules, which can be further utilized in various chemical and pharmaceutical processes.
Used in Research and Development:
Ethyl isocyanoacetate is also used in research and development for the synthesis of 7-aza-tetrahydroindoles, oxazolines, benzodiazepines, imidazoles, and oxazoles. Its role in these syntheses contributes to the advancement of scientific knowledge and the discovery of new compounds with potential applications in various industries.
Ethyl isocyanoacetate is used in the syntheses of 7-aza-tetrahydroindoles, oxazolines, benzodiazepines, imidazoles and oxazoles. For example, it is involved in the synthesis of 1H-indole-2-carboxylate by condensing with 2-bromo benzenealdehyde using CuI as a catalyst. It is a precursor used in the preparation of ethyl thiazole-4-carboxylate upon reaction with O-ethyl thioformate.
2.What is the CAS number for Ethyl isocyanoacetate ?
The CAS number of Ethyl isocyanoacetate is 2999-46-4.
More information of Ethyl isocyanoacetate 2999-46-4 are:
|
CAS?Number |
2999-46-4 |
|
Density |
1.03 g/cm3 |
|
Melting Point |
194-196 °C(lit.) |
|
Boiling Point |
194-196°C(lit.) |
|
Flash Point |
84 °C |
|
Vapor Pressure |
61.7Pa at 25℃ |
|
Refractive Index |
n20/D 1.418(lit.) |
|
HS CODE |
29299090 |
|
PSA |
26.30000 |
|
LogP |
-0.30050 |
3.What is the molecular formula of Ethyl isocyanoacetate ?
The chemical formula of?Ethyl isocyanoacetate is C5H7NO2 which containing 5 Carbon atoms,7 Hydrogen atoms,1 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight, and the molecular weight of Ethyl isocyanoacetate is 113.116
4.What is Ethyl isocyanoacetate(2999-46-4)used for?
Ethyl isocyanoacetate is a versatile cyclization synthon that is characterized by its light yellow to brown liquid appearance. It is slightly soluble in water and lye, but miscible in ethanol and ether. The material may darken upon storage, which is an important consideration for its handling and use.
Usage:
Ethyl isocyanoacetate is used as a cyclization synthon for the preparation of various heterocyclic compounds, including pyrroles, oxazolines, benzodiazepines, oxazoles, and imidazoles. Its ability to participate in the synthesis of these compounds makes it a valuable reagent in the field of organic chemistry.
Used in Pharmaceutical Industry:
Ethyl isocyanoacetate is used as a key intermediate in the synthesis of various pharmaceutical compounds. For example, it is involved in the synthesis of 1H-indole-2-carboxylate by condensing with 2-bromo benzenealdehyde using CuI as a catalyst. This application is crucial for the development of new drugs and therapeutic agents.
Used in Chemical Synthesis:
Ethyl isocyanoacetate is used as a precursor in the preparation of ethyl thiazole-4-carboxylate upon reaction with O-ethyl thioformate. This application highlights its utility in the synthesis of complex organic molecules, which can be further utilized in various chemical and pharmaceutical processes.
Used in Research and Development:
Ethyl isocyanoacetate is also used in research and development for the synthesis of 7-aza-tetrahydroindoles, oxazolines, benzodiazepines, imidazoles, and oxazoles. Its role in these syntheses contributes to the advancement of scientific knowledge and the discovery of new compounds with potential applications in various industries.
InChI:InChI=1/C5H7NO2/c1-3-4(6-2)5(7)8/h4H,3H2,1H3,(H,7,8)/p-1
Relevant articles related to Ethyl isocyanoacetate:
|
Article |
Source |
|
Dispirooxindoles based on 2-selenoxo-imidazolidin-4-ones: Synthesis, cytotoxicity and ros generation ability |
Novotortsev, Vladimir K.,Kukushkin, Maxim E.,Tafeenko, Viktor A.,Skvortsov, Dmitry A.,Kalinina, Marina A.,Timoshenko, Roman V.,Chmelyuk, Nelly S.,Vasilyeva, Liliya A.,Tarasevich, Boris N.,Gorelkin, Petr V.,Erofeev, Alexander S.,Majouga, Alexander G.,Zyk, Nikolai V.,Beloglazkina, Elena K. , p. 1 - 26 (2021) |
|
Isocyanide 2.0 |
Ahmadian-Moghaddam, Maryam,D?mling, Alexander,Patil, Pravin supporting information, p. 6902 - 6911 (2020/11/09) |
5.Factory Supply Industrial Grade Ethyl isocyanoacetate 2999-46-4 with Best Price
Jinhe Chemical Co., Ltd. is a quality supplier of Ethyl isocyanoacetate. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Ethyl isocyanoacetate 2999-46-4.